Cyanidin-3-o-glucoside liposome: Preparation via a green method and antioxidant activity in GES-1 cells

Food Res Int. 2019 Nov:125:108648. doi: 10.1016/j.foodres.2019.108648. Epub 2019 Aug 26.

Abstract

Cyanidin-3-O-glucoside (C3G) liposomes was used to improve the stability and antioxidant activity of C3G through a green thin-film dispersion method. The characteristics, stability and the effect of C3G liposomes on GES-1 cells were explored. Results showed that the particle size and encapsulation efficiency (EE%) of C3G liposomes were 258.9 ± 5.06 nm and 77.5%, respectively. DPPH assay showed that liposomes encapsulation can improve the antioxidant of C3G, while the ABTS assay was opposite. Stability study showed the C3G liposome were unstable under extended storage time. The effects of C3G liposomes on GES-1 cells showed that C3G liposomes can decrease the ROS levels of GES-1 and had negligible effects on cell viability and mitochondrial structure. These findings suggested that liposomes could be used as a carrier system to improve the stability of C3G.

Keywords: Antioxidant activity; C3G; C3G liposomes; Color stability; GES-1cells; Mitochondria structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthocyanins / administration & dosage*
  • Antioxidants / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Drug Stability
  • Glucosides / administration & dosage*
  • Liposomes / administration & dosage*
  • Liposomes / chemistry*
  • Mitochondria / drug effects
  • Particle Size
  • Reactive Oxygen Species / analysis

Substances

  • Anthocyanins
  • Antioxidants
  • Glucosides
  • Liposomes
  • Reactive Oxygen Species
  • cyanidin-3-O-beta-glucopyranoside