Defend Thyself and Thy Offspring

Anisha Pal; Vivek Nilesh Shah; Martin J Simard

doi:10.1016/j.devcel.2019.09.004

Defend Thyself and Thy Offspring

Dev Cell. 2019 Sep 23;50(6):677-679. doi: 10.1016/j.devcel.2019.09.004.

Authors

Anisha Pal¹, Vivek Nilesh Shah¹, Martin J Simard²

Affiliations

¹ St-Patrick Research Group in Basic Oncology, Centre Hospitalier Universitaire de Québec-Université Laval Research Center (L'Hôtel-Dieu de Québec), Quebec City, QC G1R 3S3, Canada; Laval University Cancer Research Centre, Quebec City, QC G1R 3S3, Canada.
² St-Patrick Research Group in Basic Oncology, Centre Hospitalier Universitaire de Québec-Université Laval Research Center (L'Hôtel-Dieu de Québec), Quebec City, QC G1R 3S3, Canada; Laval University Cancer Research Centre, Quebec City, QC G1R 3S3, Canada. Electronic address: martin.simard@crchudequebec.ulaval.ca.

PMID: 31550461
DOI: 10.1016/j.devcel.2019.09.004

Abstract

Three recent studies (Dodson and Kennedy, 2019; Lev et al., 2019; Ouyang et al., 2019) reveal that germ granule formation is necessary to protect germline-expressed genes from improper small RNA-mediated silencing. Loss of this protection leads to accumulation of small RNAs, impacting gene expression in multiple subsequent generations.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans*
Germ Cells
RNA Interference
RNA*
RNA-Binding Proteins

Substances

RNA-Binding Proteins
RNA