Diagnosis of Urinary Tract Infection in the Neuropathic Bladder: Changing the Paradigm to Include the Microbiome

Top Spinal Cord Inj Rehabil. 2019 Summer;25(3):222-227. doi: 10.1310/sci2503-222.

Abstract

Bacteriuria, a non-specific term that refers to the presence of bacteria in the urine, is common in people with neuropathic bladders. However, accurately determining when bacteriuria represents a urinary tract infection (UTI) as opposed to asymptomatic bacteriuria is difficult. There is currently no widely accepted definition of what constitutes a UTI in people with neuropathic bladders. As a result, there is significant variation in care, which likely leads to unnecessary use of antibiotics for bacteriuria. To improve the clinical management of people with neuropathic bladders, it is important to be able to accurately diagnose and treat UTIs. In this article, we review the difficulties associated with accurately diagnosing UTIs and then review proposed definitions. Finally, we discuss the emerging literature of the urinary microbiome and how this may assist in accurately diagnosing UTIs in people with neuropathic bladders.

Keywords: neuropathic bladders; urinary microbiome; urinary tract infection.

Publication types

  • Review

MeSH terms

  • Asymptomatic Infections
  • Bacteriuria / diagnosis*
  • Humans
  • Microbiota*
  • Urinary Bladder, Neurogenic / diagnosis*
  • Urinary Bladder, Neurogenic / microbiology*
  • Urinary Tract Infections / diagnosis*
  • Urinary Tract Infections / microbiology*