Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides

Org Lett. 2019 Oct 4;21(19):7782-7786. doi: 10.1021/acs.orglett.9b02731. Epub 2019 Sep 23.

Abstract

The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.

Publication types

  • Research Support, Non-U.S. Gov't