Computational tools for modern vaccine development

Hum Vaccin Immunother. 2020 Mar 3;16(3):723-735. doi: 10.1080/21645515.2019.1670035. Epub 2019 Dec 18.

Abstract

Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not only arrest the beginning of different diseases but also assign a gateway for its elimination and reduce toxicity. This review gives an overview of the possible uses of computational tools for vaccine design. Moreover, we have described the initiatives of utilizing the diverse computational resources by exploring the immunological databases for developing epitope-based vaccines, peptide-based drugs, and other resources of immunotherapeutics. Finally, the applications of multi-graft and multivalent scaffolding, codon optimization and antibodyomics tools in identifying and designing in silico vaccine candidates are described.

Keywords: Vaccine; antibodyomics tools; epitope prediction; multi-graft scaffolding; rational design; reverse vaccinology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computational Biology*
  • Epitopes
  • Peptides
  • Vaccines*

Substances

  • Epitopes
  • Peptides
  • Vaccines

Grants and funding

Authors acknowledge M.D. University, Rohtak, India, for providing infrastructural facilities. SV acknowledges the support as University Research Scholarship by M.D. University, Rohtak, India. The authors wish to acknowledge NIH fellows editorial board for the scientific editing of the manuscript. The authors also acknowledge the infrastructural support from Department of Science and Technology, New Delhi, Govt. of India, through FIST grant (Grant No. 1196 SR/FST/LS-I/ 2017/4).