Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell-derived macrophages

J Allergy Clin Immunol. 2019 Nov;144(5):1438-1441.e12. doi: 10.1016/j.jaci.2019.07.039. Epub 2019 Sep 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autophagy / genetics
  • Cell Differentiation
  • Cells, Cultured
  • Familial Mediterranean Fever / genetics*
  • Genetic Predisposition to Disease
  • Genotype*
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Inflammasomes / metabolism*
  • Macrophages / physiology*
  • Pedigree
  • Polymorphism, Genetic
  • Pruritus / genetics*
  • Pyrin / genetics*
  • RNA, Small Interfering / genetics

Substances

  • Inflammasomes
  • MEFV protein, human
  • Pyrin
  • RNA, Small Interfering