Autoimmune diseases and pregnancy

Best Pract Res Clin Endocrinol Metab. 2019 Dec;33(6):101322. doi: 10.1016/j.beem.2019.101322. Epub 2019 Sep 11.

Abstract

Pregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informed about risks that can occur taking some medications while pregnant and, on the other hand, that there are medications that can be safety assumed during pregnancy. Furthermore, there are known maternal risks factor such as the presence of antiphospholipid antibodies or anti-Ro/SSA antibodies that must be carefully manage by both rheumatologists and obstetrics. In addition, also disease activity during pregnancy can represent an issue. For all these reason, a multidisciplinary approach is mandatory in order to give our patients an optimal medical support, before, during and after pregnancy.

Keywords: autoimmune diseases; pregnancy; systematic review.

Publication types

  • Review

MeSH terms

  • Antibodies, Antinuclear / analysis
  • Antibodies, Antinuclear / blood
  • Antiphospholipid Syndrome / complications
  • Antiphospholipid Syndrome / diagnosis
  • Antiphospholipid Syndrome / immunology
  • Antiphospholipid Syndrome / therapy
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / therapy*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / therapy
  • Pregnancy
  • Pregnancy Complications / etiology
  • Pregnancy Complications / immunology*
  • Pregnancy Complications / therapy*
  • Prenatal Care / methods
  • Prenatal Care / trends
  • Risk Factors

Substances

  • Antibodies, Antinuclear
  • SS-A antibodies