Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Across the Spectrum of Hypertension

Am J Hypertens. 2020 Mar 13;33(3):207-213. doi: 10.1093/ajh/hpz157.

Abstract

Sodium glucose cotransporter 2 (SGLT2) inhibitors represent a novel class of oral antihyperglycemic drugs that have been approved over the last decade for the management of type 2 diabetes mellitus. Except the glucose-lowering effects, robust evidence also suggests that SGLT2 inhibitors confer benefits in cardiovascular system. The purpose of this review was to investigate the effects of SGLT2 inhibitors across the spectrum of arterial hypertension.

Keywords: SGLT-2 inhibitors; arterial hypertension; blood pressure; diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / therapeutic use*
  • Arterial Pressure / drug effects*
  • Humans
  • Hypertension / diagnosis
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Sodium-Glucose Transporter 2 Inhibitors / therapeutic use*
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Sodium-Glucose Transporter 2 Inhibitors