Spatiotemporal Clustering of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis Is Associated With Human Immunodeficiency Virus Status and Drug-Susceptibility Patterns in KwaZulu-Natal, South Africa

Clin Infect Dis. 2020 May 6;70(10):2224-2227. doi: 10.1093/cid/ciz913.

Abstract

Using an open-access spatiotemporal analytics program, we mapped spatiotemporal heterogeneity loci in tuberculosis (TB) cases (clusters) and dynamic changes, and characterized the drug-resistant TB clustering risk using routine microbiological data from KwaZulu-Natal, South Africa. The data may provide insight into transmission dynamics and support efficient deployment of public health resources.

Keywords: HIV; SatScan; South Africa; drug-resistant tuberculosis; spatiotemporal analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use
  • Cluster Analysis
  • Extensively Drug-Resistant Tuberculosis* / drug therapy
  • Extensively Drug-Resistant Tuberculosis* / epidemiology
  • HIV
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • Humans
  • Mycobacterium tuberculosis* / genetics
  • Pharmaceutical Preparations*
  • South Africa / epidemiology
  • Tuberculosis, Multidrug-Resistant* / drug therapy
  • Tuberculosis, Multidrug-Resistant* / epidemiology

Substances

  • Antitubercular Agents
  • Pharmaceutical Preparations