Avascular necrosis of the femoral head after single steroid intra-articular injection

Eur J Orthop Surg Traumatol. 2020 Feb;30(2):193-197. doi: 10.1007/s00590-019-02555-8. Epub 2019 Sep 19.

Abstract

Femoral head avascular bone necrosis (AVN) is the loss of blood supply to the bone tissue of femoral head that results in cellular death. This condition causes a significant limitation in patient daily life activities and has a poor functional outcome. Long-term steroid intake was established as a cause of AVN. However, few cases reported femoral head AVN post-single steroid intra-articular injection. We review all cases of AVN that results from single intra-articular steroid injection and present a case of femoral head AVN developed in a 78-year-old male. The patient, who was not known to have any medical illness, presented complaining of mild left hip pain for 4 months with long distant ambulation and weight standing. He was diagnosed to have left hip joint osteoarthritis for which he received intra-articular steroid injection 2 months prior visiting our orthopedics center. MRI of the pelvis revealed AVN of the femoral head. He underwent total hip arthroplasty. The pathological examination confirmed the diagnosis of AVN. To best of our knowledge, this is the fifth case of AVN of femoral head AVN after single intra-articular steroid injection. We reviewed all cases of AVN of femoral head after single steroid injection. Intra-articular steroid injection can cause femoral head AVN, and the patient receiving these injections should be aware about this rare but significant complication that results in poor functional outcome and significant morbidity.

Keywords: Arthroplasty; Avascular; Intra-articular; Steroids.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Femur Head / blood supply
  • Femur Head / drug effects
  • Femur Head / pathology
  • Femur Head Necrosis / chemically induced*
  • Femur Head Necrosis / pathology
  • Humans
  • Injections, Intra-Articular
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects
  • Steroids / administration & dosage
  • Steroids / adverse effects*

Substances

  • Steroids
  • Methylprednisolone