[Hepatic dysfunction in patients with cardiogenic shock]

Med Klin Intensivmed Notfmed. 2019 Oct;114(7):665-676. doi: 10.1007/s00063-019-00618-6. Epub 2019 Sep 19.
[Article in German]

Abstract

Cardiogenic shock is a life-threatening condition that is frequently associated with acute hepatic dysfunction. Due to low cardiac output resulting in end-organ hypoperfusion and hypoxia, different types of liver dysfunction can develop, such as hypoxic hepatitis or acute liver failure. A very serious and late sequela is the secondary sclerosing cholangitis in critically patients. Clinical management of acute hepatic dysfunction involves the stabilization of cardiac output to improve hepatic perfusion and the optimization of liver oxygenation. However, despite maximum efforts in supportive treatment, the outcome of patients with cardiogenic shock and concomitant hepatic dysfunction remains poor.

Keywords: Acute liver failure; Hypoxic hepatitis; Intensive care; Low-cardiac output; Secondary sclerosing cholangitis.

Publication types

  • Review

MeSH terms

  • Cholangitis, Sclerosing / diagnosis
  • Cholangitis, Sclerosing / etiology
  • Critical Illness
  • Humans
  • Hypoxia / complications*
  • Hypoxia / etiology
  • Liver / pathology*
  • Liver Failure, Acute / diagnosis*
  • Liver Failure, Acute / etiology
  • Liver Function Tests
  • Shock, Cardiogenic* / complications