The main approach for designing vertical flow (VF) treatment wetlands is based on areal requirements ranging from 2 to 4 m2 per person equivalent (PE). Other design parameters are the granularity of the filter material, filter depth, hydraulic and organic loading rates, loading intervals, amount of single doses as well as the number of openings in the distribution pipes. The influence of these parameters is investigated by running simulations using the HYDRUS Wetland Module for three VF wetlands with different granularity of the filter material (0.06-4 mm, 1-4 mm, and 4-8 mm, respectively). For each VF wetland, simulations are carried out at different temperatures for different organic loading rates, loading intervals and number of distribution points. Using coarser filter material results in reduced removal of pollutants and higher effluent concentrations if VF wetlands are operated under the same conditions. However, the treatment efficiency can be increased by applying more loadings and/or a higher density of the distribution network. For finer filter material, longer loading intervals are suggested to guarantee sufficient aeration of the VF filter between successive loadings.