A facile method for electrochemical separation of 181-186Re from proton irradiated natural tungsten oxide target

Rubel Chakravarty; Sudipta Chakraborty; Sachin Jadhav; K C Jagadeesan; S V Thakare; Ashutosh Dash

doi:10.1016/j.apradiso.2019.108885

A facile method for electrochemical separation of ^181-186Re from proton irradiated natural tungsten oxide target

Appl Radiat Isot. 2019 Dec:154:108885. doi: 10.1016/j.apradiso.2019.108885. Epub 2019 Sep 4.

Authors

Rubel Chakravarty¹, Sudipta Chakraborty², Sachin Jadhav³, K C Jagadeesan³, S V Thakare³, Ashutosh Dash³

Affiliations

¹ Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India. Electronic address: rubelc@barc.gov.in.
² Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India.
³ Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India.

PMID: 31536908
DOI: 10.1016/j.apradiso.2019.108885

Abstract

Routine availability of high specific activity ¹⁸⁶Re would provide a significant boost to the development of potent theranostic radiopharmaceuticals. In the present study, ^181-¹⁸⁶Re was produced by proton bombardment (12 MeV, average beam intensity 180 nΑ) for 60 h on natural tungsten oxide target. A facile electrochemical method has been developed for radiochemical separation of Re radioisotopes from irradiated target material. The overall yield of the process was >80% and Re radioisotopes could be separated in a form suitable for preparation of radiopharmaceuticals.

Keywords: (186)Re; DMSA; Electrochemical separation; HEDP; High specific activity; Radiolabeling; Theranostics.