Spicy Immunity: Pain to Gain

Nathachit Limjunyawong; Xinzhong Dong

doi:10.1016/j.immuni.2019.08.014

Spicy Immunity: Pain to Gain

Immunity. 2019 Sep 17;51(3):426-428. doi: 10.1016/j.immuni.2019.08.014.

Authors

Nathachit Limjunyawong¹, Xinzhong Dong²

Affiliations

¹ The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: xdong2@jhmi.edu.

PMID: 31533055
DOI: 10.1016/j.immuni.2019.08.014

Abstract

The skin is densely innervated with nociceptive neurons specialized in detecting noxious and painful stimuli. In a recent issue of Cell, Cohen et al. report that activation of cutaneous nociceptive neurons leads to a nerve-reflex action that is sufficient to provide a danger signal that triggers regional immunity to fight a microbial challenge.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Neurons
Nociceptors*
Pain*
Reflex
Skin
TRPV Cation Channels

Substances

TRPV Cation Channels
TRPV1 protein, human

Grants and funding

R01 NS054791/NS/NINDS NIH HHS/United States