Novel three-way fusions among ZNF384, EWSR1 and EHMT1 genes in paediatric B cell precursor acute lymphoblastic leukaemia with translocations resembling Philadelphia chromosomes

Br J Haematol. 2019 Nov;187(3):e75-e79. doi: 10.1111/bjh.16199. Epub 2019 Sep 18.

Authors

Xue Chen^{1

2}, Fang Wang^{1

2}, Panxiang Cao¹, Yang Zhang¹, Xiaoli Ma¹, Mingyue Liu¹, Wen Teng¹, Junfang Yang³, Jianping Zhang⁴, Tong Wang^{1

5}, Hongxing Liu^{1

2

5}

Affiliations

¹ Divison of Pathology & Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China.
² Beijing Lu Daopei Institute of Haematology, Beijing, China.
³ Department of Haematology, Hebei Yanda Lu Daopei Hospital, Langfang, China.
⁴ Department of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang, China.
⁵ Divison of Pathology & Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China.

PMID: 31531845
DOI: 10.1111/bjh.16199

No abstract available

Keywords: EWSR1; ZNF384; B-cell precursor acute lymphoblastic leukaemia; integrated genomic analysis.

Publication types

Case Reports
Letter

MeSH terms

Allografts
Child, Preschool
Female
Hematopoietic Stem Cell Transplantation
Histone-Lysine N-Methyltransferase / genetics*
Humans
Oncogene Proteins, Fusion
Pediatrics
Philadelphia Chromosome
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
RNA-Binding Protein EWS / genetics*
Trans-Activators / genetics*
Translocation, Genetic / genetics*
Treatment Outcome

Substances

EWSR1 protein, human
Oncogene Proteins, Fusion
RNA-Binding Protein EWS
Trans-Activators
ZNF384 protein, human
EHMT1 protein, human
Histone-Lysine N-Methyltransferase