[Clinical challenges and implications of intratumor heterogeneity]

Abstract

Tumors display a high, albeit variable, grade of intratumor heterogeneity, both from a clinical and a morphological viewpoint. Furthermore, recent methods of large-scale molecular analysis demonstrate to what extent tumors can also be heterogeneous from a molecular perspective. This is of paramount importance for patients as it has a great impact on the success of so-called precision therapies and explains the reason for a significant number of therapeutic failures in modern oncology. We present an up-to-date review of the latest findings in a group of tumors with a high social impact, commonly seen in the daily routine of the pathology laboratory.

Keywords: Adenocarcinoma de endometrio; Breast cancer; Carcinoma de mama; Carcinoma renal de células claras; Clear cell renal cell carcinoma; Endometrial adenocarcinoma; Heterogeneidad intratumoral; Intratumor heterogeneity; Melanoma; Molecular pathology; Patología molecular; Sarcoma; Sarcomas.