Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two-Dimensional Cell Contact Region

CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):873-877. doi: 10.1002/psp4.12468. Epub 2019 Oct 23.

Authors

Brian J Schmidt¹, Christine Bee², Minhua Han², Yawu Jing³, Yougan Cheng¹, Daniel J Tenney³, Tarek A Leil¹

Affiliations

¹ Quantitative Clinical Pharmacology, Bristol-Myers Squibb, Princeton, New Jersey, USA.
² Biologics Discovery California, Bristol-Myers Squibb, Redwood City, California, USA.
³ Leads Discovery and Optimization, Bristol-Myers Squibb, Hopewell, New Jersey, USA.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies / chemistry*
Antibodies / pharmacology*
Humans
Membrane Proteins / chemistry
Membrane Proteins / metabolism*
Models, Theoretical

Substances

Antibodies
Membrane Proteins