TP53INP2 at the crossroad of apoptosis and autophagy in death receptor signaling

Saška Ivanova; Antonio Zorzano

doi:10.1080/23723556.2019.1632687

TP53INP2 at the crossroad of apoptosis and autophagy in death receptor signaling

Mol Cell Oncol. 2019 Jun 24;6(5):e1632687. doi: 10.1080/23723556.2019.1632687. eCollection 2019.

Authors

Saška Ivanova^{1

2

3}, Antonio Zorzano^{1

2

3}

Affiliations

¹ Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
² CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain.
³ Departament de Bioquimica i Biomedicina Molecular, Universitat de Barcelona, Barcelona, Spain.

Abstract

The binding of ligands to death receptors elicits distinct outcomes, such as apoptosis, inflammation and necroptosis, depending on the cellular context. We have recently described that the autophagic protein TP53INP2 favors apoptosis upon death receptor signaling and is a potential biomarker of responsiveness to TRAIL treatment.

Keywords: TP53INP2; TRAIL; apoptosis; autophagy; death receptor signaling.

Grants and funding

This work was supported by the Generalitat de Catalunya (Grant 2017SGR1015), CIBERDEM (Instituto de Salud Carlos III), MINECO (SAF2016-75246R, the Fundació La Marató de TV3 (20132330), Fundación Ramon Areces (CIVP18A3942), the Fundación BBVA, and “la Caixa” Foundation (LCF/PR/GN14/10270002). We gratefully acknowledge institutional funding from MINECO through the Centres of Excellence Severo Ochoa Award, and from the CERCA Programme of the Generalitat de Catalunya; Fundació la Marató de TV3 [20132330]; Fundación Ramón Areces [CIVP18A3942]; Generalitat de Catalunya [Grant 2017SGR1015]; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabolicas; MINECO [SAF2016-75246R].