Hematological and biochemical parameters for Chinese rhesus macaque

Wenhai Yu; Xianhui Hao; Fengmei Yang; Jin Ma; Yuan Zhao; Yanyan Li; Junbin Wang; Hongjie Xu; Lixiong Chen; Quan Liu; Suqin Duan; Yaping Yang; Fen Huang; Zhanlong He

doi:10.1371/journal.pone.0222338

Hematological and biochemical parameters for Chinese rhesus macaque

PLoS One. 2019 Sep 17;14(9):e0222338. doi: 10.1371/journal.pone.0222338. eCollection 2019.

Authors

Wenhai Yu¹, Xianhui Hao², Fengmei Yang¹, Jin Ma¹, Yuan Zhao¹, Yanyan Li¹, Junbin Wang¹, Hongjie Xu¹, Lixiong Chen¹, Quan Liu¹, Suqin Duan¹, Yaping Yang¹, Fen Huang², Zhanlong He¹

Affiliations

¹ Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China.
² Medical Faculty, Kunming University of Science and Technology, Kunming, PR China.

Abstract

Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
China
Female
Macaca mulatta / genetics*
Macaca mulatta / physiology*
Male

Grants and funding

This study was supported by PUMC young Fund (3332019008 and 2017310038), Natural Science Foundation of Yunnan province to (2018FB132) to WY, the Fundamental Research Funds for the Central Universities (2016ZX310179-3, 2016ZX310179-4) to WY and FY, and CAMS Innovation Fund for Medical Sciences (2019-I2M-1-004, 2018-I2M-3-002, 2016-I2M-2-1-001,) to WY, YZ, and ZH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.