Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy

Feng Liu; Lin Lin; Ying Zhang; Shu Sheng; Yanbing Wang; Caina Xu; Huayu Tian; Xuesi Chen

doi:10.1016/j.biomaterials.2019.119470

Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy

Biomaterials. 2019 Dec:223:119470. doi: 10.1016/j.biomaterials.2019.119470. Epub 2019 Sep 5.

Authors

Feng Liu¹, Lin Lin², Ying Zhang¹, Shu Sheng¹, Yanbing Wang³, Caina Xu⁴, Huayu Tian⁵, Xuesi Chen⁶

Affiliations

¹ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China.
³ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China.
⁴ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China. Electronic address: xucaina@ciac.ac.cn.
⁵ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China. Electronic address: thy@ciac.ac.cn.
⁶ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China.

PMID: 31526950
DOI: 10.1016/j.biomaterials.2019.119470

Abstract

Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low drug loading content and unsatisfactory therapeutic outcome. Herein, we developed a novel nanoparticles-induced assemble strategy to construct 2D nanosheets with ultra-high curcumin loading content of 59.6 % and excellent stability in water. Furthermore, a distinct photothermal effect and multimodal imaging property after polydopamine coating could be obtained, thereby leading to precise and efficient ablation of tumor in combination of curcumin-induced chemotherapy. More importantly, the design principle of our work offers novel facile strategy to assemble metal-binding drugs into 2D nanomedicine with high drug content and well-defined shapes.

Keywords: Combined therapy; Curcumin; Polydopamine; Two-dimensional nanosheets.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Curcumin / chemistry*
Drug Delivery Systems
HeLa Cells
Humans
Hyperthermia, Induced
Indoles / chemistry
MCF-7 Cells
Metals / chemistry
Mice
Microscopy, Confocal
Multimodal Imaging
Nanomedicine
Nanoparticles / chemistry*
Neoplasm Transplantation
Neoplasms / therapy*
Phototherapy / methods*
Polymers / chemistry
Protein Binding
Theranostic Nanomedicine
Treatment Outcome
Water / chemistry

Substances

Indoles
Metals
Polymers
polydopamine
Water
Curcumin