Graphene is a two-dimensional nanomaterial composed of 1-10 layers of carbon atoms in a honeycomb lattice. It has been 15 years since the first isolation of few-layer graphene from graphite by the Scotch Tape method. Worldwide research efforts on graphene have been rewarded with enormous breakthroughs in fundamental science and innovative applications. To achieve an influential impact on society, graphene must be manufactured at large scales, be superior to existing products, and be safe to use. In this Perspective, we highlight relevant issues in the quest for commercialization of graphene-containing products. We showcase achievements in improving graphene synthesis while also discussing concerns regarding graphene standardization and graphene's impact on the environment and human health.