Background: Betel nut is the fourth most commonly abused substance worldwide and has been associated with significant adverse health outcomes. Little is known about its effects on the fetus.
Objective: To perform a systematic review of studies investigating prenatal betel nut use and adverse perinatal outcomes.
Search strategy: Pubmed, Embase, and Cochrane databases were searched from inception until July 2018 using the terms areca, betel nut, pregnancy, pregnancy complications, and infection.
Selection criteria: Eligible studies included case-control, cohort, and randomized control studies involving pregnant women.
Data collection and analysis: Where appropriate, bivariate meta-analysis was performed, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Main results: In total, 28 studies were screened and eight studies (including 15 270 women) were included in the review and meta-analysis. Preterm birth, low birthweight, and anemia were most commonly investigated. Meta-analysis revealed a significant association between betel nut use and low birthweight, with a pooled OR of 1.75 (95% CI, 1.35-2.27).
Conclusions: The review identified only eight eligible studies, all based in the Asia-Pacific region. There was a significant association between low birthweight and betel nut exposure in pregnancy. Further prospective studies are needed to confirm this association.
Keywords: Adverse outcomes; Areca; Betel nut; Pregnancy; Pregnancy complications.
© 2019 International Federation of Gynecology and Obstetrics.