This work describes in situ synthesis and application of the zinc glutamate Bio Metal-Organic Framework (BioMOF) supported on cellulose fabrics as a dual material for nitric oxide (NO) and 5-fluorouracil (5FU) controlled delivery for wound and/or skin cancer therapy. In situ synthesis of BioMOF on the cotton fabric was successfully achieved and the incorporation of NO and 5FU was studied. We have observed that BioMOF doped with FeII metal ions has a beneficial impact on NO incorporation. The products obtained were analyzed with X-ray powder diffraction (XRPD), Fourier-Transform Infrared Spectroscopy-Attenuated Total Reflectance (FTIR-ATR), Field Emission Scanning Electron Microscopy (FESEM), Diffuse Reflectance UV-Vis-NIR spectrometer, X-Ray pHotoelectron Spectroscopy (XPS), Thermogravimetric Analysis (TGA), N2 adsorption analysis, Transition UV-Visible spectroscopy, and Gas Chromatography-Mass Spectroscopy (GC-MS). Moreover, antibacterial and anticancer activity in melanoma skin cell was carried out in order to prove the biological activity of the drug-loaded BioMOF on treated cellulose fabrics. These studies are indicative of the potential of BioMOF@cellulose fabric composites for the controlled delivery of bioactive molecules on the wound and/or cancer.
Keywords: Bio metal-organic frameworks (BioMOF); Bioactive molecule delivery; Cotton fabric; Wound dressing; in situ synthesis.
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