Three new bioactive flavonoid glycosides from Viscum album

Abstract

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC₅₀ ≤ 60.00 μmol·L^-1), while the inhibition of TF-1 and Hela was not significant.

Keywords: Cytotoxic activities; Flavonoid glycosides; Viscum album.