Objective: To explore the effect of concentrated growth factors (CGF) on postoperative pain and swelling in patients with complex dental implants.
Methods: A total of 28 patients with single maxillary anterior teeth loss and labial orbital bone defect were recruited randomly and divided into two groups. Each group included 14 patients. The experimental group was applied with CGF membrane to guide bone regeneration, whereas the control group was treated with collagen membrane to guide bone regeneration. The postoperative pain degree and swelling degree were compared, and data were analyzed with SPSS 23.0 software. Postoperative pain was measured by visual analogue scale (VAS), and the degree of swelling was divided into four grades according to swelling range.
Results: VAS scores of patients in experimental and control groups reached 35.1±22.5 and 47.0±20.3, respectively. The duration of postoperative pain in experimental and control groups totaled (2.1±1.5) and (2.8±1.0) days, respectively. No statistically significant difference was observed between the two groups (P>0.05). Percentages of non-swelling, mild swelling, moderate swelling, and severe swelling in experimental group reached 21.4%, 57.1%, 21.4%, and 0, respectively, and those in control group were 7.1%, 35.7%, 35.7%, and 21.4%. Swelling duration reached (2.4±1.4) and (4.2±2.2) days in the experimental and control groups, respectively. A statistically significant difference was observed in the swelling degree of experimental and control groups (P<0.05).
Conclusions: The use of CGF can significantly reduce the degree of postoperative swelling and shorten swelling time but cause no significant effect on pain.
目的 研究浓缩生长因子（CGF）对种植骨增量患者术后疼痛和肿胀的作用。方法 选择28例单颗上颌前牙缺失伴唇侧骨板缺损可同期植入种植体的患者，随机分为2组，每组14例，试验组应用CGF行引导骨再生术，对照组应用胶原膜行引导骨再生术，分析对比两组患者术后疼痛和肿胀程度。术后疼痛采用视觉模拟评分（VAS）法测定，肿胀程度根据肿胀范围划分4个等级。采用SPSS 23.0软件包对结果进行统计分析。结果 试验组和对照组患者疼痛VAS评分分别为35.1±22.5和47.0±20.3，术后疼痛持续时间分别为（2.1±1.5）、（2.8±1.0） d，组间差异无统计学意义（P>0.05）。试验组无肿胀、轻度肿胀、中度肿胀、重度肿胀的百分比分别为21.4%、57.1%、21.4%、0，对照组依次为7.1%、35.7%、35.7%和21.4%，术后肿胀持续时间分别为（2.4±1.4）、（4.2±2.2） d，差异存在统计学意义（P<0.05）。结论 CGF的应用可以减轻患者术后肿胀程度，缩短术后肿胀时间，但对疼痛无明显作用。.
Keywords: concentrated growth factors; guided bone regeneration; postoperative reaction.