Know Thyself: RIG-I-Like Receptor Sensing of DNA Virus Infection

Yang Zhao; John Karijolich

doi:10.1128/JVI.01085-19

Know Thyself: RIG-I-Like Receptor Sensing of DNA Virus Infection

J Virol. 2019 Nov 13;93(23):e01085-19. doi: 10.1128/JVI.01085-19. Print 2019 Dec 1.

Authors

Yang Zhao¹, John Karijolich^{2

3}

Affiliations

¹ Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
² Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA John.karijolich@vanderbilt.edu.
³ Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.

Abstract

The RIG-I-like receptors (RLRs) are double-stranded RNA-binding proteins that play a role in initiating and modulating cell intrinsic immunity through the recognition of RNA features typically absent from the host transcriptome. While they are initially characterized in the context of RNA virus infection, evidence has now accumulated establishing the role of RLRs in DNA virus infection. Here, we review recent advances in the RLR-mediated restriction of DNA virus infection with an emphasis on the RLR ligands sensed.

Keywords: DNA virus; MDA5; RIG-I; RIG-I-like receptors; herpesvirus; innate immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DEAD Box Protein 58 / metabolism*
DNA Virus Infections / metabolism*
Humans
Immunity, Innate
RNA Virus Infections
RNA-Binding Proteins / metabolism*
Receptors, Immunologic
Sensory Receptor Cells / metabolism*
Transcriptome

Substances

RNA-Binding Proteins
Receptors, Immunologic
RIGI protein, human
DEAD Box Protein 58