Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

Jedidiah Whitt; Cameron Duke; Mohamad Akbar Ali; Steven A Chambers; Md Mahbub Kabir Khan; David Gilmore; Mohammad A Alam

doi:10.1021/acsomega.9b01967

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

ACS Omega. 2019 Aug 21;4(10):14284-14293. doi: 10.1021/acsomega.9b01967. eCollection 2019 Sep 3.

Authors

Jedidiah Whitt¹, Cameron Duke¹, Mohamad Akbar Ali², Steven A Chambers¹, Md Mahbub Kabir Khan¹, David Gilmore¹, Mohammad A Alam¹

Affiliations

¹ Department of Chemistry and Physics, College of Science and Mathematics and Department of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, Arkansas 72467, United States.
² Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Abstract

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

Grants and funding

P20 GM103429/GM/NIGMS NIH HHS/United States