The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

Charis L Himeda; Peter L Jones

doi:10.1016/j.devcel.2019.08.010

The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

Dev Cell. 2019 Sep 9;50(5):525-526. doi: 10.1016/j.devcel.2019.08.010.

Authors

Charis L Himeda¹, Peter L Jones²

Affiliations

¹ Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
² Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. Electronic address: peterjones@med.unr.edu.

PMID: 31505171
DOI: 10.1016/j.devcel.2019.08.010

Abstract

In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells.

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MeSH terms

Homeodomain Proteins
Humans
Immune Evasion
Muscular Dystrophy, Facioscapulohumeral*
Neoplasms*

Substances

Homeodomain Proteins