The ulnar collateral ligament (UCL) of the elbow has been a subject of extensive research and discussion in recent years not only in the medical community but also in the media and by coaches, players, and parents. This is in part due to the rising incidence of UCL injuries and subsequent surgical reconstruction, specifically in overhead throwing athletes. Due to this widespread increase in injury to this structure, it is paramount to understand when it is appropriate to pursue nonoperative versus operative management. As such, the purpose of this article will be to review the basic anatomy, risk factors for UCL injury in overhead throwing athletes, treatment approaches, and future directions for prevention and treatment of injury based on the evidence-based data in the peer-reviewed literature.