Characterization of the novel HLA-DQB1*06:01:22 allele by next-generation sequencing

HLA. 2019 Dec;94(6):543-545. doi: 10.1111/tan.13688. Epub 2019 Oct 1.

Abstract

HLA-DQB1*06:01:22 differs from HLA-DQB1*06:01:01:01 by one nucleotide substitution in codon 189 in exon 4.

Keywords: HLA typing; next-generation sequencing; novel allele.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Asian People / genetics
  • Base Sequence
  • Blood Donors*
  • China
  • Exons
  • HLA-DQ beta-Chains / genetics*
  • High-Throughput Nucleotide Sequencing*
  • Histocompatibility Testing / methods
  • Humans
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA / methods

Substances

  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen