Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion

Antimicrob Agents Chemother. 2019 Oct 22;63(11):e01024-19. doi: 10.1128/AAC.01024-19. Print 2019 Nov.

Abstract

Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC90s of Streptococcus pneumoniae and Staphylococcus aureus for ≥7 days.

Keywords: dalbavancin; lung epithelial lining fluid; pharmacodynamics; pharmacokinetics; pneumonia.

Publication types

  • Clinical Trial, Phase I
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics*
  • Humans
  • Infusions, Intravenous
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Pneumococcal / drug therapy
  • Pneumonia, Staphylococcal / drug therapy
  • Respiratory Mucosa / chemistry*
  • Staphylococcus aureus / drug effects
  • Streptococcus pneumoniae / drug effects
  • Teicoplanin / administration & dosage
  • Teicoplanin / analogs & derivatives*
  • Teicoplanin / analysis
  • Teicoplanin / blood
  • Teicoplanin / pharmacokinetics
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Teicoplanin
  • dalbavancin