Effect of denture adhesives on oral moisture: A multicenter randomized controlled trial

Yasuhiro Nishi; Taro Nomura; Mamoru Murakami; Yasuhiko Kawai; Masahiro Nishimura; Hisatomo Kondo; Yoshihiko Ito; Akito Tsuboi; Guang Hong; Suguru Kimoto; Atsuko Gunji; Asako Suzuki; Gaku Ohwada; Shunsuke Minakuchi; Yusuke Sato; Tetsuya Suzuki; Katsuhiko Kimoto; Noriyuki Hoshi; Makiko Saita; Yoshikazu Yoneyama; Yohei Sato; Masakazu Morokuma; Joji Okazaki; Takeshi Maeda; Kenichiro Nakai; Tetsuo Ichikawa; Kan Nagao; Keiko Fujimoto; Hiroshi Murata; Tadafumi Kurogi; Kazuhiro Yoshida; Toshio Hosoi; Taizo Hamada

doi:10.1016/j.jpor.2019.08.004

Effect of denture adhesives on oral moisture: A multicenter randomized controlled trial

J Prosthodont Res. 2020 Jul;64(3):281-288. doi: 10.1016/j.jpor.2019.08.004. Epub 2019 Sep 7.

Authors

Yasuhiro Nishi¹, Taro Nomura², Mamoru Murakami³, Yasuhiko Kawai⁴, Masahiro Nishimura⁵, Hisatomo Kondo⁶, Yoshihiko Ito⁷, Akito Tsuboi⁸, Guang Hong⁹, Suguru Kimoto¹⁰, Atsuko Gunji¹¹, Asako Suzuki¹², Gaku Ohwada¹³, Shunsuke Minakuchi¹⁴, Yusuke Sato¹⁵, Tetsuya Suzuki¹⁶, Katsuhiko Kimoto¹⁷, Noriyuki Hoshi¹⁸, Makiko Saita¹⁹, Yoshikazu Yoneyama²⁰, Yohei Sato²¹, Masakazu Morokuma²², Joji Okazaki²³, Takeshi Maeda²⁴, Kenichiro Nakai²⁵, Tetsuo Ichikawa²⁶, Kan Nagao²⁷, Keiko Fujimoto²⁸, Hiroshi Murata²⁹, Tadafumi Kurogi³⁰, Kazuhiro Yoshida³¹, Toshio Hosoi³², Taizo Hamada³³

Affiliations

¹ The Japan Denture Care Society, Japan; Department of Oral and Maxillofacial Prosthodontics, Field of Oral and Maxillofacial Rehabilitation, Course for Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan. Electronic address: shar@dent.kagoshima-u.ac.jp.
² The Japan Denture Care Society, Japan; Department of Prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. Electronic address: tarou.nmr@gmail.com.
³ The Japan Denture Care Society, Japan; Denture Prosthodontic Restoration, Advanced Dentistry Center, Kagoshima University Medical and Dental Hospital, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan. Electronic address: kaku@dent.kagoshima-u.ac.jp.
⁴ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-nishi, Matsudo, Chiba 271-8587, Japan. Electronic address: kawai.yasuhiko@nihon-u.ac.jp.
⁵ The Japan Denture Care Society, Japan; Department of Oral and Maxillofacial Prosthodontics, Field of Oral and Maxillofacial Rehabilitation, Course for Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan. Electronic address: mnishi@dent.kagoshima-u.ac.jp.
⁶ The Japan Denture Care Society, Japan; Department of Prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. Electronic address: hkondo@iwate-med.ac.jp.
⁷ The Japan Denture Care Society, Japan; Division of Aging and Geriatric Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: y-itoh@dent.tohoku.ac.jp.
⁸ The Japan Denture Care Society, Japan; Division of Community Oral Health Science, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan. Electronic address: tsuboi@m.tohoku.ac.jp.
⁹ The Japan Denture Care Society, Japan; Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: hong@m.tohoku.ac.jp.
¹⁰ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-nishi, Matsudo, Chiba 271-8587, Japan. Electronic address: kimoto.suguru@nihon-u.ac.jp.
¹¹ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-nishi, Matsudo, Chiba 271-8587, Japan. Electronic address: gunji.atsuko@nihon-u.ac.jp.
¹² The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Nihon University Graduate School of Dentistry at Matsudo, 2-870-1 Sakaecho-nishi, Matsudo, Chiba 271-8587, Japan. Electronic address: maas14013@g.nihon-u.ac.jp.
¹³ The Japan Denture Care Society, Japan; Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan. Electronic address: g.ohwada.gerd@tmd.ac.jp.
¹⁴ The Japan Denture Care Society, Japan; Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan. Electronic address: s.minakuchi.gerd@tmd.ac.jp.
¹⁵ The Japan Denture Care Society, Japan; Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan. Electronic address: y.sato.gerd@tmd.ac.jp.
¹⁶ The Japan Denture Care Society, Japan; Section of Oral Prosthetic Engineering, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan. Electronic address: suzuki.peoe@tmd.ac.jp.
¹⁷ The Japan Denture Care Society, Japan; Division of Prosthodontics & Oral Implantology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. Electronic address: k.kimoto@kdu.ac.jp.
¹⁸ The Japan Denture Care Society, Japan; Division of Prosthodontics & Oral Implantology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. Electronic address: hoshi@kdu.ac.jp.
¹⁹ The Japan Denture Care Society, Japan; Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan. Electronic address: saita@kdu.ac.jp.
²⁰ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Kanagawa 230-8501, Japan. Electronic address: yoneyama-y@tsurumi-u.ac.jp.
²¹ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Kanagawa 230-8501, Japan. Electronic address: sato-yohei@tsurumi-u.ac.jp.
²² The Japan Denture Care Society, Japan; Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Kanagawa 230-8501, Japan. Electronic address: info@morokumashika.com.
²³ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 1-5-17 Otemae, Chuo-ku, Osaka 540-0008, Japan. Electronic address: joji@cc.osaka-dent.ac.jp.
²⁴ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 1-5-17 Otemae, Chuo-ku, Osaka 540-0008, Japan. Electronic address: maeda-t@cc.osaka-dent.ac.jp.
²⁵ The Japan Denture Care Society, Japan; Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 1-5-17 Otemae, Chuo-ku, Osaka 540-0008, Japan. Electronic address: nakai-ks@cc.osaka-dent.ac.jp.
²⁶ The Japan Denture Care Society, Japan; Department of Oral and Maxillofacial Prosthodontics, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. Electronic address: ichi@tokushima-u.ac.jp.
²⁷ The Japan Denture Care Society, Japan; Department of Oral and Maxillofacial Prosthodontics, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. Electronic address: kan@tokushima-u.ac.jp.
²⁸ The Japan Denture Care Society, Japan; Department of Oral and Maxillofacial Prosthodontics, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. Electronic address: c301451014@tokushima-u.ac.jp.
²⁹ The Japan Denture Care Society, Japan; Department of Prosthetic Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan. Electronic address: hmurata@nagasaki-u.ac.jp.
³⁰ The Japan Denture Care Society, Japan; Department of Prosthetic Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan. Electronic address: kurofumi@nagasaki-u.ac.jp.
³¹ The Japan Denture Care Society, Japan; Department of Prosthetic Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan. Electronic address: kyoshida@nagasaki-u.ac.jp.
³² The Japan Denture Care Society, Japan; Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Kanagawa 230-8501, Japan. Electronic address: hosoi-t@tsurumi-u.ac.jp.
³³ The Japan Denture Care Society, Japan; Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, Hiroshima 734-8553, Japan. Electronic address: thamada66@gmail.com.

PMID: 31501069
DOI: 10.1016/j.jpor.2019.08.004

Abstract

Purpose: The purpose of this study was to investigate the effect of denture adhesives on oral moisture in a 10-center parallel randomized clinical trial.

Methods: Two hundred edentulous subjects wearing complete dentures were allocated into three groups: cream-type adhesive, powder-type adhesive and control groups. The adhesives (and saline solution in the control group) were applied to the mucosal surface of the dentures for 4 days, and baseline data and data after the intervention for eight meals over 4 days were obtained. For the main outcome, oral moisture was measured with a moisture checking device. Secondary outcomes were denture satisfaction, masticatory performance, denture retention, and occlusal force. In addition to between-group and within-group comparisons of oral moisture, investigations for secondary outcomes were undertaken in subgroups classified according to the degree of oral moisture at baseline (normal subgroup and dry mouth subgroup). Intention-to-treat analysis was also performed.

Results: Between-group and within-group comparisons of oral moisture showed no significant differences. The cream-type and powder-type denture adhesives were significantly effective in the dry mouth group for denture satisfaction ratings of ability to masticate, stability, retention, and comfort of mandibular dentures (p<0.05). The masticatory performance and retentive force of the dry mouth denture adhesive using groups were significantly improved after intervention (p<0.05).

Conclusions: The oral moisture of complete denture wearers was not influenced by the use of denture adhesives. Our findings showed that denture adhesives improved subjective denture satisfaction, masticatory performance, and retention for complete denture patients with oral dryness.

Keywords: Denture adhesive; Moisture-checker; Oral moisture; RCT.

Publication types

Multicenter Study
Randomized Controlled Trial

MeSH terms

Dental Cements*
Denture Retention
Denture, Complete
Humans
Mastication
Mouth, Edentulous*

Substances

Dental Cements