True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity

Luke Riggan; Aharon G Freud; Timothy E O'Sullivan

doi:10.1016/j.it.2019.08.005

True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity

Trends Immunol. 2019 Oct;40(10):909-921. doi: 10.1016/j.it.2019.08.005. Epub 2019 Sep 6.

Authors

Luke Riggan¹, Aharon G Freud², Timothy E O'Sullivan³

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 900953, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Pathology, Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
³ Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 900953, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: tosullivan@mednet.ucla.edu.

Abstract

Innate lymphoid cells (ILCs) consist of a heterogeneous family of lymphocytes that regulate tissue homeostasis and can contribute to pathology in mice and humans. Mammalian group 1 ILCs are defined by the production of interferon (IFN)-γ and the functional dependence on the transcription factor T-bet. While recent studies demonstrate that group 1 ILCs consist of circulating mature natural killer (NK) cells and tissue-resident ILC1s, the functional, phenotypic, and developmental properties that distinguish these two cell lineages are often confusing and difficult to dissect. In this review, we critically evaluate the current knowledge of mammalian group 1 ILC heterogeneity and propose new inclusive nomenclature to clarify the roles of ILC1s and NK cells during homeostasis and disease.

Keywords: ILC; NK cell; group 1 ILCs; heterogeneity.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Immunity, Innate / immunology*
Killer Cells, Natural / immunology
Lymphocyte Subsets / immunology*

Abstract

Publication types

MeSH terms

Grants and funding