Direct-write and sacrifice-based techniques for vasculatures

Shuai Li; Kan Wang; Qingxi Hu; Chuck Zhang; Ben Wang

doi:10.1016/j.msec.2019.109936

Direct-write and sacrifice-based techniques for vasculatures

Mater Sci Eng C Mater Biol Appl. 2019 Nov:104:109936. doi: 10.1016/j.msec.2019.109936. Epub 2019 Jul 3.

Authors

Shuai Li¹, Kan Wang², Qingxi Hu³, Chuck Zhang⁴, Ben Wang⁵

Affiliations

¹ Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA 30332, USA; Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
² Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: kwang34@mail.gatech.edu.
³ Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai 200072, China; National Demonstration Center for Experimental Engineering Training Education, Shanghai University, Shanghai 200444, China. Electronic address: huqingxi@shu.edu.cn.
⁴ Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA 30332, USA; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
⁵ Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA 30332, USA; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

PMID: 31500055
DOI: 10.1016/j.msec.2019.109936

Abstract

Fabricating biomimetic vasculatures is considered one of the greatest challenges in tissue regeneration due to their complex structures across various length scales. Many strategies have been investigated on how to fabricate tissue-engineering vasculatures (TEVs), including vascular-like and vascularized structures that can replace their native counterparts. The advancement of additive manufacturing (AM) technologies has enabled a wide range of fabrication techniques that can directly-write TEVs with complex and delicate structures. Meanwhile, sacrifice-based techniques, which rely on the removal of encapsulated sacrificial templates to form desired cavity-like structures, have also been widely studied. This review will specifically focus on the two most promising methods in these recently developed technologies, which are the direct-write method and the sacrifice-based method. The performance, advantages, and shortcomings of each technique are analyzed and compared. In the discussion, we list current challenges in this field and present our vision of next-generation TEVs technologies. Perspectives on future research in this field are given at the end.

Keywords: Additive manufacturing; Direct-write; Sacrifice-based technique; Vasculature.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / pharmacology
Blood Vessels / drug effects
Blood Vessels / physiology*
Humans
Neovascularization, Physiologic / drug effects
Polymers / pharmacology
Printing, Three-Dimensional
Tissue Engineering / methods*

Substances

Biocompatible Materials
Polymers