Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy

Dianwei Wang; Zhe Zhang; Lin Lin; Feng Liu; Yanbing Wang; Zhaopei Guo; Yanhui Li; Huayu Tian; Xuesi Chen

doi:10.1016/j.biomaterials.2019.119459

Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy

Biomaterials. 2019 Dec:223:119459. doi: 10.1016/j.biomaterials.2019.119459. Epub 2019 Aug 30.

Authors

Dianwei Wang¹, Zhe Zhang², Lin Lin², Feng Liu³, Yanbing Wang¹, Zhaopei Guo², Yanhui Li⁴, Huayu Tian⁵, Xuesi Chen⁶

Affiliations

¹ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
³ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China.
⁵ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China. Electronic address: thy@ciac.ac.cn.
⁶ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China.

PMID: 31499253
DOI: 10.1016/j.biomaterials.2019.119459

Abstract

Combination of photodynamic therapy (PDT) and photothermal therapy (PTT) generally requires different components to build a composite irradiated with different excitation lights. One component photoactive agent for enhanced combination of PDT and PTT under the excitation of a single wavelength light source is more urgent in tumor phototherapy via adjusting spatial arrangement of photoactive units. Herein, porphyrin-based covalent organic framework nanoparticles (COF-366 NPs) were synthesized to control the orderly spatial arrangement of the photoactive building units and firstly used for antitumor therapy in vivo. COF-366 NPs provide the simultaneous therapy of PDT and PTT under a single wavelength light source with the monitoring of photoacoustic (PA) imaging, which makes the operation simpler and more convenient. COF-366 NPs had achieved good phototherapy effect even in the face of large tumors. The prepared multifunctional COF-366 NPs open up a new avenue to phototherapeutic materials and expand the application range of covalent organic framework.

Keywords: Covalent organic framework; Photoacoustic imaging; Photodynamic and photothermal therapy; Single wavelength light irradiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzofurans / chemistry
Cell Line, Tumor
Combined Modality Therapy
Female
Hemolysis
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles / chemistry*
Neoplasm Transplantation
Neoplasms / therapy*
Neoplasms, Experimental / therapy
Organic Chemicals
Photoacoustic Techniques*
Phototherapy*
Porphyrins / chemistry*
Rabbits
Reactive Oxygen Species / chemistry

Substances

Benzofurans
Organic Chemicals
Porphyrins
Reactive Oxygen Species
1,3-diphenylisobenzofuran