Interleukin-13 Is Unlucky for Allergy Sufferers

Markus M Xie; Alexander L Dent

doi:10.1016/j.tips.2019.08.007

Interleukin-13 Is Unlucky for Allergy Sufferers

Trends Pharmacol Sci. 2019 Oct;40(10):714-716. doi: 10.1016/j.tips.2019.08.007. Epub 2019 Sep 5.

Authors

Markus M Xie¹, Alexander L Dent²

Affiliations

¹ Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
² Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: adent2@iupui.edu.

PMID: 31493932
DOI: 10.1016/j.tips.2019.08.007

Abstract

Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.

Keywords: Tfh13; allergy; anaphylaxis.

Publication types

Comment

MeSH terms

Allergens
Anaphylaxis*
Humans
Immunoglobulin E
Interleukin-13*
T-Lymphocytes, Helper-Inducer / immunology

Substances

Allergens
Interleukin-13
Immunoglobulin E