Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Valentina Trapani; Federica I Wolf

doi:10.1016/j.ceca.2019.102078

Dysregulation of Mg²⁺ homeostasis contributes to acquisition of cancer hallmarks

Cell Calcium. 2019 Nov:83:102078. doi: 10.1016/j.ceca.2019.102078. Epub 2019 Aug 31.

Authors

Valentina Trapani¹, Federica I Wolf²

Affiliations

¹ Istituto di Patologia Generale, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: valentina.trapani@unicatt.it.
² Istituto di Patologia Generale, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 31493712
DOI: 10.1016/j.ceca.2019.102078

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg²⁺ channels and other Mg²⁺ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg²⁺ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

Keywords: Cyclin M; Invasion; Metabolism; Proliferation; Solute carrier; Transient receptor potential melastatin type.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomarkers, Tumor / metabolism*
Cell Membrane / metabolism*
Cell Proliferation
Homeostasis
Humans
Neoplasms / metabolism*
Protein Conformation
Protein Domains / genetics
Structure-Activity Relationship
Transient Receptor Potential Channels / metabolism*

Substances

Biomarkers, Tumor
Transient Receptor Potential Channels