Systematic review and multi-modal meta-analysis of magnetic resonance imaging findings in 22q11.2 deletion syndrome: Is more evidence needed?

Cristina Scarpazza; Guido Maria Lattanzi; Mathilde Antoniades; Fabio Di Fabio; Giuseppe Sartori; Simon B Eickhoff; Philip McGuire; Stefania Tognin

doi:10.1016/j.neubiorev.2019.09.004

Systematic review and multi-modal meta-analysis of magnetic resonance imaging findings in 22q11.2 deletion syndrome: Is more evidence needed?

Neurosci Biobehav Rev. 2019 Dec:107:143-153. doi: 10.1016/j.neubiorev.2019.09.004. Epub 2019 Sep 4.

Authors

Cristina Scarpazza¹, Guido Maria Lattanzi¹, Mathilde Antoniades², Fabio Di Fabio³, Giuseppe Sartori⁴, Simon B Eickhoff⁵, Philip McGuire², Stefania Tognin⁶

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of General Psychology, University of Padua, Padua, Italy.
² Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
³ Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
⁴ Department of General Psychology, University of Padua, Padua, Italy.
⁵ Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
⁶ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Electronic address: stefania.tognin@kcl.ac.uk.

PMID: 31493414
DOI: 10.1016/j.neubiorev.2019.09.004

Abstract

22q11.2 deletion syndrome (DS) is considered to be the most robust genetic model of psychosis. In the last decade, there has been increased interest in the brain abnormalities associated with these genetic changes. Most imaging findings in this population come from small samples. This increases the risk of reporting spurious effects that reflect the idiosyncrasies of each study. Thus, the current work is aimed at identifying whether there are spatially consistent structural and functional brain abnormalities in individuals with 22q11.2 DS through (i) a comprehensive label-based systematic review and (ii) a coordinate-based meta-analysis of magnetic resonance imaging studies. The systematic review identified the frontal middle gyri, posterior cingulum, right cuneus and bilateral precuneus as the most affected regions. The meta-analysis revealed consistent abnormalities in the bilateral inferior parietal lobe, right precuneus, right superior temporal gyrus and posterior cingulate cortex. This study provides an important starting point for future research as it sheds light on possible genetically determined psychosis susceptibility regions.

Keywords: 22q11.2 deletion syndrome; DTI; Genetic model; Meta-analysis; Structural MRI; Systematic review; fMRI.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Brain / diagnostic imaging*
Brain Mapping
DiGeorge Syndrome / diagnostic imaging*
Humans
Magnetic Resonance Imaging
Nerve Net / diagnostic imaging*