From White to Brown - Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice

Justin Darcy; Andrzej Bartke

doi:10.1007/978-3-030-25650-0_11

From White to Brown - Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice

Adv Exp Med Biol. 2019:1178:207-225. doi: 10.1007/978-3-030-25650-0_11.

Authors

Justin Darcy¹, Andrzej Bartke²

Affiliations

¹ Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. justin.darcy@joslin.harvard.edu.
² Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA.

PMID: 31493229
DOI: 10.1007/978-3-030-25650-0_11

Abstract

Growth hormone (GH) is a metabolic hormone that has major functions in the liver, muscle, and adipose tissue (AT). In the past 20 years, numerous studies have demonstrated that decreased growth hormone (GH) action is clearly linked to alterations in longevity. Therefore, it is not surprising that mechanisms underlying the extended longevity of GH-mutant animals include alterations in AT function. This Review aims to describe the basics of AT biology, GH secretion and action, and the effects of altered GH signaling in mice and humans. Lastly, this Review discusses the intersection of GH and AT, and how the influence of GH on AT may play a critical role in determining lifespan and healthspan.

Keywords: Aging; Brown adipose tissue; Growth hormone; Longevity; White adipose tissue.

Publication types

Review

MeSH terms

Adipose Tissue, Brown* / physiology
Adipose Tissue, White / physiology
Animals
Growth Hormone* / genetics
Humans
Longevity* / physiology
Mice
Signal Transduction

Substances

Growth Hormone