A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol

Molecules. 2019 Sep 5;24(18):3239. doi: 10.3390/molecules24183239.

Abstract

Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation.

Keywords: 3,4-dihydroxyphenylglycol; hydroxytyrosol; hydroxytyrosol acetate; large scale synthesis; microwave irradiation; nutraceutical.

MeSH terms

  • Chemistry Techniques, Synthetic* / methods
  • Humans
  • Methoxyhydroxyphenylglycol / analogs & derivatives*
  • Methoxyhydroxyphenylglycol / chemical synthesis
  • Methoxyhydroxyphenylglycol / chemistry
  • Molecular Structure
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / chemical synthesis
  • Phenylethyl Alcohol / chemistry

Substances

  • 3,4-dihydroxyphenylethanol
  • Methoxyhydroxyphenylglycol
  • Phenylethyl Alcohol
  • 3,4-dihydroxyphenylglycol