ICAM-1 in HIV infection and underlying mechanisms

Xiaowen Yu; Hong Shang; Yongjun Jiang

doi:10.1016/j.cyto.2019.154830

ICAM-1 in HIV infection and underlying mechanisms

Cytokine. 2020 Jan:125:154830. doi: 10.1016/j.cyto.2019.154830. Epub 2019 Sep 3.

Authors

Xiaowen Yu¹, Hong Shang², Yongjun Jiang³

Affiliations

¹ NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China.
² NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China. Electronic address: hongshang100@hotmail.com.
³ NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China. Electronic address: jiangjun55555@163.com.

PMID: 31491723
DOI: 10.1016/j.cyto.2019.154830

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein that participates in inflammatory and immune responses. Both cell surface and soluble ICAM-1 are significantly increased during human immunodeficiency virus (HIV) infection, and ICAM-1 has important functions in promoting inflammatory responses and enhancing HIV infectivity; however, a comprehensive summary these roles has yet to be elaborated. In this review we describe the general biological characteristics of ICAM-1, its association with HIV disease progression and promotion of HIV production, mechanisms inducing upregulation of ICAM-1, and possible intervention strategies, representing important insights in the context of HIV treatment.

Keywords: Disease progression; HIV; ICAM-1; Mechanism; sICAM-1.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Child
Cytokines / blood
Disease Progression
HIV Infections / immunology*
HIV Infections / metabolism
HIV Infections / virology
HIV-1 / immunology*
Humans
Inflammation / immunology
Inflammation / metabolism
Inflammation / virology
Intercellular Adhesion Molecule-1 / blood
Intercellular Adhesion Molecule-1 / metabolism*

Substances

Cytokines
ICAM1 protein, human
Intercellular Adhesion Molecule-1