Recent progress in structural studies on canonical TRP ion channels

Wenjun Guo; Lei Chen

doi:10.1016/j.ceca.2019.102075

Recent progress in structural studies on canonical TRP ion channels

Cell Calcium. 2019 Nov:83:102075. doi: 10.1016/j.ceca.2019.102075. Epub 2019 Aug 28.

Authors

Wenjun Guo¹, Lei Chen²

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
² State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: chenlei2016@pku.edu.cn.

PMID: 31491644
DOI: 10.1016/j.ceca.2019.102075

Abstract

Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and the cytoplasmic domains of TRPC channels.

Keywords: BTDM; Ion channel; TRP; TRPC.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cryoelectron Microscopy
Crystallography, X-Ray
Extracellular Space
Humans
Protein Conformation
Protein Domains / genetics
Structure-Activity Relationship
Transient Receptor Potential Channels / genetics
Transient Receptor Potential Channels / metabolism*

Substances

Transient Receptor Potential Channels