Method for Evaluating Neuromodulatory Properties of Dental Pulp Stem Cell as an In Vitro Model for Parkinson's Disease

Methods Mol Biol. 2020:2125:193-196. doi: 10.1007/7651_2019_261.

Abstract

Several research groups have utilized dental pulp stem cells for numerous studies as treatment modality for Parkinson's disease (PD). However, the roles of dental pulp stem cells in governing the Parkinson's disease inflammatory microenvironment remain to be evaluated. In this article, we elaborate the method where we can investigate the effects of dental pulp stem cells on neurons and microglia in an in vitro inflammatory microenvironment.

Keywords: Deciduous tooth; Dental pulp stem cell; Parkinson’s disease (PD); Regenerative medicine; SHED.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Culture Techniques / methods*
  • Dental Pulp / pathology*
  • Humans
  • Models, Biological*
  • Parkinson Disease / pathology*
  • Stem Cells / pathology*
  • Tooth, Deciduous / pathology