Persistent adult acne is one of the most difficult types of acne to treat. It is a long-lasting disease with uncontrolled exacerbations that often result in scarring. The aim of this study was to analyze the influence of acne therapy used in adolescence on patients who later developed persistent adult acne. The use of oral antibiotics, isotretinoin, and topical retinoids in adolescence and their role in diminishing scar formation during adult acne was analyzed. This population-based study included 111 patients, 91 of whom had persistent adult acne. Results indicated that the use of isotretinoin or topical retinoids for adolescent acne decreased the risk for scar occurrence in adulthood.