Corneal refractive surgery combined with simultaneous corneal cross-linking: Indications, protocols and clinical outcomes-A review

Clin Exp Ophthalmol. 2020 Jan;48(1):78-88. doi: 10.1111/ceo.13621. Epub 2019 Oct 2.

Abstract

Corneal refractive surgery is one of the most common approaches for correction of refractive errors. Combined corneal refractive surgery and corneal cross-linking (CXL) has been proposed as a method to achieve better refractive stability and to prevent iatrogenic corneal ectasia. However, there are concerns regarding its indications, surgical safety, standardization of protocols and long-term effect on corneal tissue. This review article aims to discuss the current knowledge and recent updates on combination of CXL and refractive surgery.

Keywords: cornea; corneal cross-linking; refractive surgery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Collagen / metabolism
  • Combined Modality Therapy
  • Corneal Pachymetry
  • Corneal Stroma / drug effects
  • Corneal Stroma / metabolism
  • Corneal Surgery, Laser / methods*
  • Cross-Linking Reagents* / therapeutic use
  • Humans
  • Photochemotherapy / methods*
  • Photosensitizing Agents / therapeutic use*
  • Refraction, Ocular / physiology
  • Refractive Errors / drug therapy
  • Refractive Errors / physiopathology
  • Refractive Errors / therapy*
  • Riboflavin / therapeutic use*
  • Ultraviolet Rays
  • Visual Acuity / physiology

Substances

  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Collagen
  • Riboflavin