A combined view of B-cell epitope features in antigens

Nayem Zobayer; Abm Aowlad Hossain; Md Asadur Rahman

doi:10.6026/97320630015530

A combined view of B-cell epitope features in antigens

Bioinformation. 2019 Aug 15;15(7):530-534. doi: 10.6026/97320630015530. eCollection 2019.

Authors

Nayem Zobayer¹, Abm Aowlad Hossain², Md Asadur Rahman¹

Affiliations

¹ Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh.
² Department of Electronics and Communication Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh.

Abstract

B-cell epitope mapping is a promising approach to identify therapeutics and vaccine candidates in antigenic proteins. We used MATLAB programming to view in combination different features such as beta turn region, surface accessibility, antigenicity and hydrophilicity in an antigen sequence to help predict a discontinuous, conformational B-cell epitope. We analyzed, grouped, compared, matched and superposed these features for a combined visualization using MATLAB programming for identifying and illustrating a potential B-cell epitope region in an antigen protein. This protocol finds application in the design and development of an effective B cell epitope candidate.

Keywords: B-cell; antigens; combined; epitope.