[Meta Analysis of Risks of Cardiocerebral Vascular Events in Patients with Primary Biliary Cholangitis]

Xi Xie; Sheng Tang; Jia Wang; Jin Wei Chen; Jing Tian; Ni Mao; Yi Ming Liu; Fen Li

doi:10.3881/j.issn.1000-503X.10637

[Meta Analysis of Risks of Cardiocerebral Vascular Events in Patients with Primary Biliary Cholangitis]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Aug 30;41(4):457-463. doi: 10.3881/j.issn.1000-503X.10637.

[Article in Chinese]

Authors

Xi Xie¹, Sheng Tang², Jia Wang¹, Jin Wei Chen¹, Jing Tian¹, Ni Mao¹, Yi Ming Liu¹, Fen Li¹

Affiliations

¹ Department of Rheumatology,the Second Xiangya Hospital of Central South University,Changsha 410011,China.
² Department of Internal Medicine,Yongzhou Hospital of Traditional Chinese Medicine,Yongzhou,Hunan 425000,China.

PMID: 31484606
DOI: 10.3881/j.issn.1000-503X.10637

Abstract

To systematically evaluate the risks of cardiocerebral vascular events in patients with primary biliary cholangitis(PBC). Methods We carried out a Meta analysis by RevMan 5.3 software to investigate literatureon the risk of cardiocerebral vascular events in patients with PBC and controls. Results Compared with non-PBC controls,PBC patients had significantly higher risk of coronary events(RR=1.56,P=0.0002);however,the risk of cerebrovascular events showed no significant difference between these two groups(RR=1.01,P=0.94).Subgroup analysis demonstrated a significantly lower risk of transient ischemic attack or carotid stenosis in PBC patients(RR=0.63,P=0.03);however,there was no significant difference in the risk of stroke(RR=1.11,P=0.40). Conclusion Patients with PBC have an increased risk of coronary events but may have a lower risk of transient ischemic attack or carotid stenosis.

Publication types

Meta-Analysis

MeSH terms

Carotid Stenosis / etiology
Cholangitis / complications*
Coronary Disease / etiology*
Humans
Ischemic Attack, Transient / etiology
Liver Cirrhosis, Biliary / complications*
Risk Factors
Stroke / etiology