Objective: To evaluate the clinical effects of functional neck dissection (FND) and supraomohyoid neck dissection (SOND) in patients with cN0/N1 oral squamous cell carcinoma (OSCC). Methods: A total of 210 patients with stage cN0/N1 OSCC underwent FND and SOND between January 2012 and May 2015 were retrospectively reviewed, among which, 147 patients were male and 63 were female, with an age range of 23-82 years and mean age of (62.2±10.2) years. There were 112 and 98 patients in FND and SOND groups, respectively. The follow-up data included cervical lymph node metastasis, movement of shoulder joint, great auricular nerve function, recurrence rate of cervical lymph nodes. Results: There was no significant difference in gender, age, tumor location, T stage, N stage, histological grades between the two groups (all P>0.05). Compared to patients in FND group, the activities of shoulder joint and earlobe numbness improved significantly in SOND group. Of the 210 patients, 17 patients (8.1%) had cervical recurrence, with 9 patients (8.0%) in FND group and 8 patients (8.2%) in SOND group. No significant difference was observed for neck recurrence between the two groups (P=0.973). Conclusion: SOND can be safely performed in cN0 or cN1 OSCC patients, which avoids major complications of FND, and improves postoperative quality of life in those patients.
目的： 探讨功能性颈淋巴结清扫术（FND）与肩胛舌骨肌上颈淋巴结清扫术（SOND）在cN0/N1期口腔鳞状细胞癌中的临床疗效。 方法： 回顾性分析。青岛大学附属医院口腔颌面外科2012年1月至2015年5月期间收治的行颈淋巴结清扫术的口腔鳞状细胞癌患者共计210例，其中男147例，女63例，年龄23~82（62.2±10.2）岁，行FND 112例（FND组），行SOND 98例（SOND组）。随访两组患者的颈部淋巴结转移情况、肩外展功能、耳大神经功能、颈部复发率，并进行比较分析。 结果： FND与SOND两组间在性别、年龄、肿瘤部位、T分期、N分期、组织学分化程度方面差异均无统计学意义（均P>0.05）。术后随访结果显示，SOND组术后肩关节活动度、耳垂感觉麻木情况优于FND组；210例患者中颈部复发17例，占8.1%，其中FND组9例（8.0%），SOND组8例（8.2%），两组比较差异无统计学意义（P=0.973）。 结论： 对于cN0/N1期口腔鳞状细胞癌患者，与FND相比，行SOND的患者颈部复发率相似，但其并发症减少，可明显提高患者术后生活质量。.
Keywords: Comparative effectiveness research; Neck dissection; Oral squamous cell carcinoma.