The Therapeutic Potential of miR-7 in Cancers

Miao Li; Meng Pan; Chengzhong You; Jun Dou

doi:10.2174/1389557519666190904141922

The Therapeutic Potential of miR-7 in Cancers

Mini Rev Med Chem. 2019;19(20):1707-1716. doi: 10.2174/1389557519666190904141922.

Authors

Miao Li¹, Meng Pan^{1

2}, Chengzhong You³, Jun Dou¹

Affiliations

¹ Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing 210009, China.
² Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
³ Department of General Surgery, Zhongda Hospital, Affiliated to Southeast University, Nanjing 210009, China.

PMID: 31483230
DOI: 10.2174/1389557519666190904141922

Abstract

MiRNAs play an important role in cancers. As a potent tumor suppressor, miRNA-7(miR-7) has been demonstrated to inhibit the diverse fundamental biological processes in multiple cancer types including initiation, growth and metastasis by targeting a number of molecules and signaling pathways. This current review summarizes and discusses the relationship between miR-7 and cancers and the therapeutic potential of miR-7 in cancers. It may provide new integrative understanding for future study on the role of miR-7 in cancers.

Keywords: RISC; cancer cell signaling; ceRNA; miR-7; therapy; tumors..

Publication types

Review

MeSH terms

Cell Proliferation / drug effects
Humans
MicroRNAs / genetics
MicroRNAs / metabolism
MicroRNAs / pharmacology*
MicroRNAs / therapeutic use*
Neoplasms / drug therapy*
Neoplasms / pathology

Substances

MIRN7 microRNA, human
MicroRNAs