Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF103_01B) Identified from Hebei Province, China

AIDS Res Hum Retroviruses. 2020 Mar;36(3):234-241. doi: 10.1089/AID.2019.0196. Epub 2019 Oct 9.

Abstract

We reported a novel HIV-1 circulating recombinant form (CRF) among three epidemiologically unlinked patients through men having sex with men in Hebei Province, China. It was named CRF103_01B (this is temporary as we have not received the CRF number from HIV databases). A near full-length genome phylogenetic tree showed that CRF103_01B was generated by three B (Western origin) segments and CRF01_AE that was described as cluster 5 lineage of CRF01_AE (CRF01-5). The emergence of CRF103_01B increased the complexity of the HIV-1 epidemic in China.

Keywords: CRF103_01B; China; Hebei.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / epidemiology
  • Genetic Variation
  • Genome, Viral*
  • Genotype
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • HIV-1 / genetics*
  • Humans
  • Male
  • Phylogeny
  • RNA, Viral / genetics
  • Recombination, Genetic*
  • Sequence Analysis, DNA*
  • Sexual and Gender Minorities
  • Young Adult

Substances

  • RNA, Viral